![]() ![]() ![]() Additional details on molecular analyses are available in the Supplemental Methods. 15 Lymphoid-specific mCAs were not analyzed. 23 For this study, mCA refers to myeloid mCA and “ambiguous” mCA that were common to both myeloid and lymphoid malignancy. ![]() Returned single nucleotide polymorphism (SNP) array data (“Return 3094”) 20, 21 were used to independently annotate mosaic chromosomal abnormalities (mCAs) using estimated break points and relevance to hematologic malignancies according to the cBioPortal for Cancer Genomics 22 and the Atlas of Genetics and Cytogenetics in Oncology and Haematology. Of the 438,890 individuals eligible for study, 193,743 were used for model derivation and 245,147 were used for validation (Fig. 19 Individuals with low abundance clones (defined by a VAF <0.02), missing laboratory values, and myeloid malignancy preceding or within 6 months of study enrollment were excluded from the analysis. 2, 17, 18 A list of included genes and average coverage per gene has been published previously. Detection of somatic variants in whole-exome sequencing was as previously described, 15 and pathogenic somatic variants in at least one gene associated with CH or myeloid malignancy were used to define CH. UKB 16 data were extracted under application 50834 from a cohort of 502,490 participants 40 to 70 years of age recruited between 20. ![]()
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